This is the definitive collection of the ethical work of the great Oxford moral philosopher H. A. Prichard. Prichard is famous for his ethical intuitionism: he argued that moral obligation cannot be reduced to anything else, but is perceived by direct intuition. The essays previously included in the posthumous collection Moral Obligation are now augmented by a selection of previously unpublished writings from Prichard's manuscripts, allowing for the first time a full view of his distinctive contribution to (...) moral philosophy, at just the time when intuitionism is enjoying a revival of interest. (shrink)

A promise to do some action seems to create a binding obligation to do that action. And yet, paradoxically, an obligation seems not to be a fact that we can create or bring into existence; we can create an obligation only by creating or bringing into existence something else. The only way to avoid the paradox is to show that the act of promising creates something other than an obligation, which nonetheless binds us to perform the action in question. After (...) considering and rejecting various options such as the promisee's expectation and the promisor's resolve, Prichard locates the bindingness of a promise in a prior general promise, which allows the noises we make when promising to generate an obligation to perform the promised action. (shrink)

This is the definitive collection of the ethical work of the great Oxford moral philosopher H. A. Prichard. Prichard is famous for his ethical intuitionism: he argued that moral obligation cannot be reduced to anything else, but is perceived by direct intuition. The essays previously included in the posthumous collection Moral Obligation are now augmented by a selection of previously unpublished writings from Prichard's manuscripts, allowing for the first time a full view of his distinctive contribution to (...) moral philosophy, at just the time when intuitionism is enjoying a revival of interest. (shrink)

Probably to most students of Moral Philosophy there comes a time when they feel a vague sense of dissatisfaction with the whole subject. And the sense of dissatisfaction tends to grow rather than to diminish. It is not so much that the positions, and still more the arguments, of particular thinkers seem unconvincing, though this is true. It is rather that the aim of the subject becomes increasingly obscure. "What," it is asked, "are we really going to learn by Moral (...) Philosophy?" "What are books on Moral Philosophy really trying to show, and when their aim is clear, why are they so unconvincing and artificial?" And again: "Why is it so difficult to substitute anything better?" Personally, I have been led by growing dissatisfaction of this kind to wonder whether the reason may not be that the subject, at any rate as usually understood, consists in the attempt to answer an improper question. And in this article, I shall venture to contend that the existence of the whole subject, as usually understood, rests on a mistake, and on a mistake parallel to that on which rests, as I think, the subject usually called the Theory of Knowledge. (shrink)

Prichard's concern here is whether a person's obligation depends either on features of his or her situation or on features of his or her thoughts about that situation. Related to this contrast between the objective view and the subjective view is the issue of whether an obligation is an obligation to do some action. To the latter issue, Prichard responds that an obligation is not an obligation to do something, but an obligation to set ourselves to do something; (...) as a consequence, it is necessary to modify the terms of Prichard's primary concern. This modification diminishes the force of the objective view and does nothing to eliminate the central difficulty in the subjective view, namely, that the obligation to do some action is said to depend not on the character that the action would have, but on our belief that it would have that character. The belief that some general character picks out obligations derives from the mistaken habit of regarding the terms ‘right’ and ‘wrong’ as equivalent to ‘ought’ and ‘ought not’. Having highlighted this mistake, Prichard holds that in instances where we have considered the circumstances fully, our thoughts about the situation decide whether we ought to perform a given activity. (shrink)

I have for some time found it increasingly difficult to resist a conclusion so heretical that the mere acceptance of it may seem a proof of lunacy. Yet the failure of a recent attempt to resist it has led me to want to confess the heresy. And at any rate a statement of my reasons may provoke a refutation.

Maintaining that the existence of Moral Philosophy, as it is usually understood, rests on a mistake, Prichard undertakes to formulate our true attitude towards moral obligations. The right action does not depend upon either our own good or what is good. Obligations are underivative, immediate, and self‐evident, and therefore, we do not come to appreciate them through argument or a process of non‐moral thinking. The mistake on which Moral Philosophy rests, which links obligation to virtue or desire, parallels the (...) mistake underpinning the Theory of Knowledge. Like moral obligation, knowledge is immediate; it need not be vindicated or improved by additional knowledge. (shrink)

To the question ‘What is the basis of moral obligation?’, argues that there is no general answer. It is improper to imply that all right acts are right for the same reason. Before defending this view, considers two possible grounds for moral obligation: 1) the goodness of the effects of an action, and 2) the goodness of the act itself. Whereas the former, which is broadly utilitarian, fails to comply with our real moral convictions, the latter does not capture well (...) the role that motive plays in determining the rightness of an action. Moral principles are not deducible either from one single principle or from anything that is not a principle. Each is independent and possesses its own reason as the basis for a given moral obligation. (shrink)

To the many moral theorists who have sought to establish a necessary connection between duty and interest, Prichard replies that their project ought not to be undertaken as it commits us to the view that our only duty is to do what is to our advantage. In discussing the attempts of Plato, Butler, and Green to link duty and interest, Prichard, like Kant, maintains that the rightness of action does not depend either upon our own good or upon (...) our belief that it depends upon our own good. Similarly, Prichard dismisses the view that our desire for our own good is our only motive. (shrink)

Examines four principle questions about moral obligation raised by key philosophers: Plato asks in The Republic ‘Will a man be better off for doing his duty?’; Plato then asks ‘Ought man to do his duty?’; we may also ask ‘What is the criterion of a duty?’; and we may ask ‘What is moral obligation?’ Rejecting the last question as unreal, Prichard then argues against the connection between duty and happiness or duty and personal or general advantage. After critiquing both (...) teleological and quasi‐teleological theories of obligation, he ends by contrasting goodness and obligation. (shrink)

Concerning the nature of desires that pertain to actions, considers the view that we cannot desire something unless we know or think, first, that it does not exist, and second, that it does not exist now. Finds a core of truth in this, but modifies the formula to claim that ‘we can only desire the existence of that of the existence of which in the past, present, or future, as the case may be, we are uncertain.’ Put more simply, a (...) desire is not a desire for the existence of something, but rather a desire for something to be. It follows from this view that we cannot desire something to be the case when we think that, without a doubt, it will be the case. (shrink)

Analyses Green's rather obscure treatment of two important questions: ‘Why does a subject have the duty to obey the ruler or sovereign?’; and ‘Why is the receipt of an order backed by a threat sufficient to establish this duty when the order comes from a ruler?’ Prichard considers Green's position regarding the grounds and justification for obedience to law to be part of a larger theory of moral obligation that is inconsistent with our ordinary moral ideas. To Green's seeming (...) denial of the existence of any natural rights or duties, Prichard responds that Green in fact has failed to state a sense in which there really are natural rights and obligations. Moreover, Green's denial that we can answer the question ‘Why ought we to obey the government?’ can be formulated only by maintaining the existence of an obligation independent of our government's commands. The core of truth in Green's position, according to Prichard, lies in his recognition that a factor necessary to secure obedience is the subject's unselfish interest in the welfare of other members of her community. (shrink)

Endeavours to specify what Aristotle means by αγαθον. In some contexts, this term seems to mean simply ‘that being desired’ or a person's ultimate or non‐ultimate end or aim. In other contexts, αγαθον takes on a normative quality. For his statements to have content, argues Prichard, Aristotle must hold that when we pursue something of a certain kind, such as an honour, we pursue it as a good. Prichard argues that by αγαθον Aristotle actually means ‘conducive to happiness’, (...) and holds that when a man acts deliberately, he does it from a desire to be happy. Prichard attributes this position to Plato as well, despite the fact that both thinkers make statements inconsistent with this view of our ultimate aim. (shrink)

Often an action causes both evil and benefit for the agent. No general account can be given for what happens when one considers in light of this evil and benefit whether to undertake the action in question. Prichard maintains that in willing a movement, there are two acts of will. First, there is the willing to think more of what one shall gain in willing x, which results from the desire to will x. Second, there is the willing of (...) the change x. (shrink)

I have for some time found it increasingly difficult to resist a conclusion so heretical that the mere acceptance of it may seem a proof of lunacy. Yet the failure of a recent attempt to resist it has led me to want to confess the heresy. And at any rate a statement of my reasons may provoke a refutation.

In discussing the fact that it takes time to perform an action, distinguishes statements such as ‘I shall do x’ from statements such as ‘I shall be under an obligation to do x’ and ‘I was doing x’ from ‘I was under an obligation to do x’. The truth of the ‘ought’ statements is independent of whether the action is done, as it is not necessary that one not do the action at the time required in order to be under (...) an obligation to do it at that time. For some contrasts between ‘ought’ and ‘is’ statements, the obligation, such as the obligation to go to bed, refers to the future. The statement ‘I am under an obligation to go to bed’ is equivalent to ‘from now on I shall be under an obligation to go to bed’, and does not require either that I shall not do the action or that I have not done the action for it to be true. (shrink)

To ascertain the truth about the main problems of moral philosophy, Prichard begins by dismissing as unreal the question ‘What is moral obligation?’ Being sui generis, ‘moral obligation’ cannot be defined in terms of other things. We are left with the question ‘What makes right acts right?’, to which Prichard replies there is no general answer. We are also left with the question ‘What, if anything, ought we to do in life?’ After contrasting the moral and the non‐moral (...) senses of ought, Prichard replies to Sidgwick's utilitarian treatment of this question, which involves dividing the question into two: ‘What ought I to do?’ and ‘What ought I to aim at?’ Dismissing the latter formulation, Prichard defends an intuitionist account of how we come to know what we ought to do. He concludes by distinguishing between the right and the good. (shrink)

Discusses central aspects of Kant's work on the nature of morality and the basis of moral obligation. In examining the categorical imperative and the hypothetical imperative, emphasizes the real nature of the distinction between these principles: whereas the former is binding upon every one, the latter is binding only upon some individuals, namely those individuals who want the end for which a prescribed action is a means. Also considers the nature of the will, Kant's criterion of the rightness of a (...) right action, and two criticisms of Kant's view of morality that arise from his attempt to offer a general answer to the question ‘Why ought an action be performed?’ Then turns to Kant's proof of freedom, which it is claimed just barely misses making the right point that action is only possible under the idea of freedom. Concludes by examining Kant's proof of immortality and the existence of God. (shrink)

For any teacher, student or practitioner of the architecture and the law of states, the passing of John Rawls, over a year later, is doubtless still providing an unusual moment in modern liberal de...

Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

As the rising costs of lifestyle-related diseases place increasing strain on public healthcare systems, the individual’s role in disease may be proposed as a healthcare rationing criterion. Literature thus far has largely focused on retrospective responsibility in healthcare. The concept of prospective responsibility, in the form of a lifestyle contract, warrants further investigation. The responsibilisation in healthcare debate also needs to take into account innovative developments in mobile health technology, such as wearable biometric devices and mobile apps, which may change (...) how we hold others accountable for their lifestyles. Little is known about public attitudes towards lifestyle contracts and the use of mobile health technology to hold people responsible in the context of healthcare. This paper has two components. Firstly, it details empirical findings from a survey of 81 members of the United Kingdom general public on public attitudes towards individual responsibility and rationing healthcare, prospective and retrospective responsibility, and the acceptability of lifestyle contracts in the context of mobile health technology. Secondly, we draw on the empirical findings and propose a model of prospective intention-based lifestyle contracts, which is both more aligned with public intuitions and less ethically objectionable than more traditional, retrospective models of responsibility in healthcare. (shrink)

About one third of patients with epilepsy have seizures refractory to the medical treatment. Electrical stimulation mapping is the gold standard for the identification of “eloquent” areas prior to resection of epileptogenic tissue. However, it is time-consuming and may cause undesired side effects. Broadband gamma activity recorded with extraoperative electrocorticography during cognitive tasks may be an alternative to ESM but until now has not proven of definitive clinical value. Considering their role in cognition, the alpha and beta bands could further (...) improve the identification of eloquent cortex. We compared gamma, alpha and beta activity, and their combinations for the identification of eloquent cortical areas defined by ESM. Ten patients with intractable focal epilepsy participated in a delayed-match-to-sample task, where syllable sounds were compared to visually presented letters. We used a generalized linear model approach to find the optimal weighting of each band for predicting ESM-defined categories and estimated the diagnostic ability by calculating the area under the receiver operating characteristic curve. Gamma activity increased more in eloquent than in non-eloquent areas, whereas alpha and beta power decreased more in eloquent areas. Diagnostic ability of each band was close to 0.7 for all bands but depended on multiple factors including the time period of the cognitive task, the location of the electrodes and the patient’s degree of attention to the stimulus. We show that diagnostic ability can be increased by 3–5% by combining gamma and alpha and by 7.5–11% when gamma and beta were combined. We then show how ECoG power modulation from cognitive testing can be used to map the probability of eloquence in individual patients and how this probability map can be used in clinical settings to optimize ESM planning. We conclude that the combination of gamma and beta power modulation during cognitive testing can contribute to the identification of eloquent areas prior to ESM in patients with refractory focal epilepsy. (shrink)

Given its non-invasive nature, there is increasing interest in the use of transcutaneous vagus nerve stimulation across basic, translational and clinical research. Contemporaneously, tVNS can be achieved by stimulating either the auricular branch or the cervical bundle of the vagus nerve, referred to as transcutaneous auricular vagus nerve stimulation and transcutaneous cervical VNS, respectively. In order to advance the field in a systematic manner, studies using these technologies need to adequately report sufficient methodological detail to enable comparison of results between (...) studies, replication of studies, as well as enhancing study participant safety. We systematically reviewed the existing tVNS literature to evaluate current reporting practices. Based on this review, and consensus among participating authors, we propose a set of minimal reporting items to guide future tVNS studies. The suggested items address specific technical aspects of the device and stimulation parameters. We also cover general recommendations including inclusion and exclusion criteria for participants, outcome parameters and the detailed reporting of side effects. Furthermore, we review strategies used to identify the optimal stimulation parameters for a given research setting and summarize ongoing developments in animal research with potential implications for the application of tVNS in humans. Finally, we discuss the potential of tVNS in future research as well as the associated challenges across several disciplines in research and clinical practice. (shrink)

Given its non-invasive nature, there is increasing interest in the use of transcutaneous vagus nerve stimulation across basic, translational and clinical research. Contemporaneously, tVNS can be achieved by stimulating either the auricular branch or the cervical bundle of the vagus nerve, referred to as transcutaneous auricular vagus nerve stimulation and transcutaneous cervical VNS, respectively. In order to advance the field in a systematic manner, studies using these technologies need to adequately report sufficient methodological detail to enable comparison of results between (...) studies, replication of studies, as well as enhancing study participant safety. We systematically reviewed the existing tVNS literature to evaluate current reporting practices. Based on this review, and consensus among participating authors, we propose a set of minimal reporting items to guide future tVNS studies. The suggested items address specific technical aspects of the device and stimulation parameters. We also cover general recommendations including inclusion and exclusion criteria for participants, outcome parameters and the detailed reporting of side effects. Furthermore, we review strategies used to identify the optimal stimulation parameters for a given research setting and summarize ongoing developments in animal research with potential implications for the application of tVNS in humans. Finally, we discuss the potential of tVNS in future research as well as the associated challenges across several disciplines in research and clinical practice. (shrink)

1 Evidence-based policy requires researchers to provide the answers to ecological questions that are of interest to policy makers. To find out what those questions are in the UK, representatives from 28 organizations involved in policy, together with scientists from 10 academic institutions, were asked to generate a list of questions from their organizations. 2 During a 2-day workshop the initial list of 1003 questions generated from consulting at least 654 policy makers and academics was used as a basis for (...) generating a short list of 100 questions of significant policy relevance. Short-listing was decided on the basis of the preferences of the representatives from the policy-led organizations. 3 The areas covered included most major issues of environmental concern in the UK, including agriculture, marine fisheries, climate change, ecosystem function and land management. 4 The most striking outcome was the preference for general questions rather than narrow ones. The reason is that policy is driven by broad issues rather than specific ones. In contrast, scientists are frequently best equipped to answer specific questions. This means that it may be necessary to extract the underpinning specific question before researchers can proceed. 5 Synthesis and applications. Greater communication between policy makers and scientists is required in order to ensure that applied ecologists are dealing with issues in a way that can feed into policy. It is particularly important that applied ecologists emphasize the generic value of their work wherever possible. (shrink)

This is the definitive collection of the ethical work of the great Oxford moral philosopher H. A. Prichard (1871-1947). Prichard is famous for his ethical intuitionism: he argued that moral obligation cannot be reduced to anything else, but is perceived by direct intuition. The essays previously included in the posthumous collection Moral Obligation are now augmented by a selection of previously unpublished writings from Prichard's manuscripts, allowing for the first time a full view of his distinctive contribution (...) to moral philosophy, at just the time when intuitionism is enjoying a revival of interest. (shrink)

Biobanks and biospecimen collections are becoming a primary means of delivering personalized diagnostics and tailoring individualized therapeutics. This shift towards precision medicine requires interactions among a variety of stakeholders, including the public, patients, healthcare providers, government, and donors. Very few studies have investigated the role of healthcare students in biobanking and biospecimen donations. The main aims of this study were to evaluate the knowledge of senior healthcare students about biobanks and to assess the students’ willingness to donate biospecimens and the (...) factors influencing their attitudes. A cross-sectional study was conducted among senior healthcare students at King Abdulaziz University, Saudi Arabia. The data were obtained using a self-administered questionnaire in English. In addition to the respondents’ biographical data section, the questionnaire assessed the respondents’ general knowledge about biobanking, the factors influencing their willingness to donate biospecimens to biobanks and their general attitudes towards biomedical research. A total of 597 senior healthcare students were included in the study. The general knowledge score was 3.2 out of 7. Only approximately 44% and 27% of students were aware of the terms “Human Genome Project” and “biobank,” respectively. The majority of the students were willing to donate biospecimens to biobanks. Multiple factors were significantly associated with their willingness to donate, including their perceived general health, past experience with both tissue testing and tissue donation, biobanking knowledge score and biomedical research attitude score. The main reasons for students’ willingness to donate were advancement of medical research and societal benefits, whereas misuse of biospecimens and confidentiality breaches were the main reasons for a reluctance to donate. Despite their strong willingness to donate biospecimens, students exhibited a notable lack of knowledge about biobanking and the HGP. To expedite the transition towards PM, it is highly recommended to enhance healthcare curricula by including more educational and awareness programmes to familiarize students with OMICs technologies in addition to the scope of research and clinical applications. (shrink)

To the question ‘What does it mean to act or to do something?’, replies that it is not easy to identify a common character in actions. Begins by examining the position of Cook Wilson, who maintains that ‘to do something’ means to originate, cause, or bring into existence, either directly or indirectly, some not yet existing state either in oneself or some other body. Although Prichard agrees that usually action involves causing something, he observes that causing a change is (...) not itself an activity. In moving one's hand, one performs that indefinable mental activity of willing some change. The movement of the hand is the effect of the action, not the action itself, a fact overlooked by thinkers like Locke. Turning to the nature of the desire behind one's willing, Prichard rejects the view that this desire is actually a desire for the change willed. Despite forceful objections, Prichard maintains that this desire is the desire for the willing of that change. (shrink)

Stephen Darwall, Allan Gibbard, and Peter Railton formulate two objections to moral sensibility theories in their overview of twentieth-century moral theory, “Toward Fin de siècle Ethics: Some Trends.” Instead of using the work of sensibility theorists John McDowell and David Wiggins to address these objections, I turn to H. A. Prichard and P. F. Strawson. The reason for doing so is that the objections misunderstand the importance of the idea of the autonomy of the moral domain. Prichard and (...) Strawson have provided important defenses of this idea that are independent of moral sensibility theories. Hence their work provides independent grounds for answering the two objections. Particularly important is the loosely a posteriori way they make their arguments. oral. (shrink)